早发性血液肿瘤具有“家族聚集性”?还与患者的发病年龄密切相关?
仅供医学专业人士阅读参考
不仅是患者,这类血液肿瘤患者家属也要警惕患癌风险!
血液恶性肿瘤具有显著家族聚集性,
HL:3~8倍 NHL:约2倍 ALL:3~7倍 AML:1.5~6倍 骨髓增生异常综合征(MDS):6~11倍
早发性HM具有家族聚集性,
HL:9.09 vs.5.61
NHL:4.61 vs.3.10
ALL/LBL:4.42 vs..3.13
AML:8.29 vs.6 .47
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[3]Rönkkö,R.,Hirvonen,E.,Malila,N.,Kilpivaara,O.,Wartiovaara-Kautto,U.and Pitkäniemi,J.(2021),Familial aggregation of early-onset haematological malignancies.Br J Haematol.
[4]Kharazmi E,Fallah M,Pukkala E,Olsen JH,Tryggvadottir L,Sundquist K,et al.Risk of familial classical Hodgkin lymphoma by relationship,histology,age,and sex:a joint study from five Nordic countries.Blood.2015;126(17):1990–5.
本文首发:医学界血液频道
本文作者:遣之 萝卜秃
责任编辑:Amelia
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●有没有兄弟姐妹这事儿竟然还与ALL/AML患儿的生存率相关?看看研究怎么说!